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Model picks & player props
San Francisco 49ers
VS
Indianapolis Colts

San Francisco 49ers vs Indianapolis Colts Picks & Predictions

Model updated Sep 10, 5:27AM UTC

We checked every price on this game against our own numbers. The green ones are the bets worth more than they should be.

NFL
Indianapolis
Tue 23 Dec 2025, 1:15AM
2
Game markets graded
0
Props graded
The model's one call for this gamethe prediction, first
Over 46.5 Total Points -105

The model graded 2 markets for San Francisco 49ers vs Indianapolis Colts (NFL) and this is the one it backs hardest — a lean, not a lock. A $100 bet returns about $195 if it lands. This one is free — every other market and all player props are Pro. Tip-off Tue 23 Dec 2025, 1:15AM at Indianapolis.

Our confidenceLean
Chance to win54.8%
The price says51.3%
Best price-105
The rest of this game's boardgraded market by market
Total Points Over 46.5 Lean55% chance -105
Total Points Lean55% chance —
High = 60%+ chance to win · Lean = 40–60% · Long-shot = under 40%
Every NFL game on today's board →

San Francisco 49ers and Indianapolis Colts last met on Tue 23 Dec 2025. What follows is the model's graded record from that game; a new preview appears here the moment the next one is priced. Today's board: every NFL game priced right now.

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This game is done — the model’s call CASHED
Over 46.5 · $100 returned $195

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Every pick is logged and graded — nothing hidden after the fact. See the verified record
Our call on this game: 2 picks on the board · logged before tip-offSee the picks

Game picks

GOOD PRICE in green
Total Points
Over
46.5
-105
+ 1 more market
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All 2 game markets and 0 player props for this matchup — every line, every call the model backs — plus every pick across the slate. Join 56,727+ members.

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Calibrated model vs market

Our chance vs the price, market by market
PickMarketModel lean
OverTotal PointsThe model likes this price 🔒 Unlock with Pro
OverTotal PointsThe model likes this price 🔒 Unlock with Pro

Which price is actually worth taking?

Pro shows you, in plain English, how far each price is off — and how much to put on it. No maths needed on your side.

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Injuries & who's out

Injuries & availability

San Francisco 49ers

  • George Kittle TEQuestionable
  • Alfred Collins DTOut
  • Dre Greenlaw LBQuestionable
  • Renardo Green CBQuestionable
  • Romello Height DEQuestionable
  • Kyle Juszczyk FBQuestionable
  • Nick Bosa DEQuestionable
  • James Thompson Jr. DTQuestionable
  • Mykel Williams DEOut
  • Gracen Halton DTQuestionable
  • Nate Hobbs CBOut
  • Sam Okuayinonu DTOut
  • Nick Martin LBOut

Indianapolis Colts

  • Drew Ogletree TEQuestionable
  • Alec Pierce WRQuestionable
  • Sedrick Van Pran-Granger CQuestionable
  • Carson Towt TEOut
  • Sean McKeon TEQuestionable
  • A.J. Haulcy SQuestionable
  • D.J. Montgomery WROut
  • Will Mallory TEOut
  • Cameron Mitchell CBOut
Availability updated Sep 9, 11:30PM UTC — NFL availability is season-pending (off-season); treat as a placeholder until the season opens. · refreshed roughly every 4 hours.

Weather & injury impact for this fixture

Conditions · who's out · how it moves the number
For San Francisco 49ers vs Indianapolis Colts: Weather isn't a tracked factor for this fixture, and 22 players are listed out or questionable across both sides.
FactorThis fixture
Availability22 listed out or questionable (see Who's out above)

General rule: sustained wind above ~15 mph and hard cold both drag NFL totals and kicking numbers down, while a key skill-position player being out shifts target and touch share to his backups.

Pro — weather & injury-adjusted view

See the weather- and injury-adjusted projected line and the model's with/without delta for this fixture. 🔒 Unlock with Pro

Betting angles

Markets & form
MoneylineIndianapolis Colts to winNo line posted

Indianapolis Colts vs San Francisco 49ers moneyline — the live line, our model's read and how the free board has gone so far, tracked every game week on BetBetter.

Point SpreadIndianapolis Colts spreadNo line posted

Indianapolis Colts vs San Francisco 49ers spread — the live line, our model's read and how the free board has gone so far, tracked every game week on BetBetter.

Total Points49ers @ ColtsNo line posted

Indianapolis Colts vs San Francisco 49ers game total — the live line, our model's read and how the free board has gone so far, tracked every game week on BetBetter.

San Francisco 49ers @ Indianapolis Colts — what the model found

Our model graded 2 betting markets for San Francisco 49ers at Indianapolis Colts — 2 on the game itself and 0 on individual players. One pick is free on this page.

2
Game markets graded

The model checked every betting market for this game and graded 2 of them. One pick is free on this page — the one the model likes most. Scroll down to see it.

🔒 The other 1 graded call for this game — with how much to bet on each — are for members.
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San Francisco 49ers vs Indianapolis Colts — recent results

Indianapolis Colts have won 0 of their last 4 games; San Francisco 49ers have won 3 of their last 5.

Indianapolis Colts — last 4
ResultScoreOpponentWhere
L16–25DETHome
L6–34ATLHome
D13–13NEAway
L30–38HOUAway
San Francisco 49ers — last 5
ResultScoreOpponentWhere
W18–12LVAway
W41–17LACAway
L13–19TENHome
L6–41SEAAway
W23–19PHIAway

Who’s out or in doubt

22 players are listed as out or in doubt for this game.

Indianapolis Colts
PlayerStatus
Drew Ogletree TEQUESTIONABLE
Alec Pierce WRQUESTIONABLE
Sedrick Van Pran-Granger CQUESTIONABLE
Carson Towt TEOUT
Sean McKeon TEQUESTIONABLE
A.J. Haulcy SQUESTIONABLE
D.J. Montgomery WROUT
Will Mallory TEOUT
San Francisco 49ers
PlayerStatus
George Kittle TEQUESTIONABLE
Alfred Collins DTOUT
Dre Greenlaw LBQUESTIONABLE
Renardo Green CBQUESTIONABLE
Romello Height DEQUESTIONABLE
Kyle Juszczyk FBQUESTIONABLE
Nick Bosa DEQUESTIONABLE
James Thompson Jr. DTQUESTIONABLE

The full availability report — with what each missing player means for the bets — is further down this page.

Track record for this matchup

Logged & graded
2
Total Picks
—
Hit Rate

Hit rate is how often the pick landed — not profit; favourites can win often and still lose money.

DateMarketPickResult
23 Dec 25 Total Points Over 46.5 ✓ HIT
23 Dec 25 Total Points Over 45.5 ✓ HIT

About this matchup

How we read the game

This page tracks the Bet Better model's pick history and predictions for San Francisco 49ers vs Indianapolis Colts in the NFL. You may also see this matchup written as 49ers vs Colts, or as Colts vs 49ers. The most recent game between them was Tuesday 23 December 2025 at Indianapolis. The model has generated 2 game picks for this matchup. Review the picks and historical data above to guide your NFL betting strategy for this matchup.

Head-to-head record

Final scores · 3 meetings on record
Indianapolis Colts 2–1 across the last 3 meetings (meetings on record since 2017)
DateGameScoreWinner
22 Dec 2025San Francisco 49ers @ Indianapolis Colts27–48San Francisco 49ers
24 Oct 2021Indianapolis Colts @ San Francisco 49ers18–30Indianapolis Colts
8 Oct 2017San Francisco 49ers @ Indianapolis Colts26–23Indianapolis Colts

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